Concepedia

Endosomal Escape

Endosomal Escape is a critical intracellular process in gene delivery wherein therapeutic nucleic acids or vectors translocate from the endosomal compartment into the cytosol, thereby avoiding lysosomal degradation and enabling subsequent gene expression.

282

Publications

24.8K

Citations

1.7K

Authors

519

Institutions

Publications per year

2017–2026

135

Parents

Children

Publications

282

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Jérôme Gilleron, William Querbes, Anja Zeigerer et al. · Nature Biotechnology · 2013 · 1.6K citations

, , +17

The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

Jean‐Paul Behr · CHIMIA International Journal for Chemistry · 1997 · 921 citations · Full text

, , +17

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno et al. · Molecular Therapy · 2018 · 794 citations · Full text

, , +16

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

Rikke Vicki Benjaminsen, Maria Ahlm Mattebjerg, Jonas R. Henriksen et al. · Molecular Therapy · 2012 · 716 citations · Full text

, , +17

Breaking down the barriers: siRNA delivery and endosome escape

Monika Domińska, Derek M. Dykxhoorn · Journal of Cell Science · 2010 · 626 citations

, , +17

1–5 of 282

Authors

1.7K

  1. KK
    Kazunori Kataoka

    The University of Tokyo, Japan

    9 publications · 815 citations

    9

    h-index

  2. SF
    Shiroh Futaki

    Kyoto University, Japan

    8 publications · 870 citations

    8

    h-index

  3. HH
    Hideyoshi Harashima

    Hokkaido University, Japan

    7 publications · 833 citations

    7

    h-index

  4. KM
    Kanjiro Miyata

    The University of Tokyo, Japan

    7 publications · 737 citations

    7

    h-index

  5. KN
    Kristina Najjar

    Texas A&M University, United States

    6 publications · 393 citations

    6

    h-index

1–5 of 1.7K

Institutions

519

  1. Kyoto University

    Kyoto, Japan

    11 h-index

    29 publications

    2.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    64 publications

    9.4K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    8 h-index

    21 publications

    3.2K citations

  4. Kyoto University Institute for Chemical Research

    Kyoto, Japan

    8 h-index

    20 publications

    1.5K citations

  5. Monash University

    Melbourne, Australia

    8 h-index

    34 publications

    2.3K citations

  6. Texas A&M University

    College Station, United States

    8 h-index

    52 publications

    3.1K citations

  7. Kyoto Bunkyo University

    Uji, Japan

    8 h-index

    20 publications

    1.5K citations

  8. The University of Tokyo

    Tokyo, Japan

    7 h-index

    50 publications

    5.7K citations

1–8 of 519

Venues

  1. Journal of Controlled Release

    16 publications · 1.3K citations

    16

    h-index

  2. Bioconjugate Chemistry

    11 publications · 515 citations

    11

    h-index

  3. Biomaterials

    10 publications · 994 citations

    10

    h-index

  4. Nanoscale

    8 publications · 459 citations

    8

    h-index

  5. Molecular Pharmaceutics

    8 publications · 307 citations

    8

    h-index

1–5