Concepedia

Endosomal Escape Efficiency

Endosomal Escape Efficiency is a quantitative metric that measures the proportion of therapeutic agents successfully translocated from endosomes into the cytosol relative to the total internalized dose, distinguishing itself from other delivery efficacy metrics by specifically capturing the bottleneck of endosomal membrane penetration in intracellular delivery systems.

206

Publications

16.6K

Citations

1.3K

Authors

436

Institutions

Publications per year

2017–2026

108

Parents

Publications

206

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Jérôme Gilleron, William Querbes, Anja Zeigerer et al. · Nature Biotechnology · 2013 · 1.6K citations

, , +17

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno et al. · Molecular Therapy · 2018 · 794 citations · Full text

, , +16

Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework

Shahad K. Alsaiari, Sachin Patil, Mram Alyami et al. · Journal of the American Chemical Society · 2017 · 504 citations

, , +17

Endosomal escape: A bottleneck for LNP-mediated therapeutics

Sushmita Chatterjee, Edo Kon, Preeti Sharma · Proceedings of the National Academy of Sciences · 2024 · 474 citations · Full text

, , +17

The great escape: how cationic polyplexes overcome the endosomal barrier

Tanja Buś, Anja Traeger, Ulrich S. Schubert · Journal of Materials Chemistry B · 2018 · 402 citations

, , +16

1–5 of 206

Authors

1.3K

  1. SF
    Shiroh Futaki

    Kyoto University, Japan

    9 publications · 956 citations

    9

    h-index

  2. HH
    Hideyoshi Harashima

    Hokkaido University, Japan

    7 publications · 844 citations

    7

    h-index

  3. KK
    Kazunori Kataoka

    The University of Tokyo, Japan

    7 publications · 643 citations

    7

    h-index

  4. KM
    Kanjiro Miyata

    The University of Tokyo, Japan

    6 publications · 610 citations

    6

    h-index

  5. SC
    Stefaan C. De Smedt

    Ghent University, Belgium

    5 publications · 227 citations

    5

    h-index

1–5 of 1.3K

Institutions

436

  1. Kyoto University

    Kyoto, Japan

    11 h-index

    22 publications

    2.2K citations

  2. Hokkaido University

    Sapporo, Japan

    9 h-index

    45 publications

    5.3K citations

  3. Collaborative Innovation Center of Chemical Science and Engineering Tianjin

    Tianjin, China

    9 h-index

    21 publications

    1K citations

  4. Kyoto University Institute for Chemical Research

    Kyoto, Japan

    9 h-index

    16 publications

    1.4K citations

  5. Kyoto Bunkyo University

    Uji, Japan

    9 h-index

    16 publications

    1.4K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    37 publications

    1.6K citations

  7. Monash University

    Melbourne, Australia

    7 h-index

    30 publications

    2.3K citations

  8. Tianjin University

    Tianjin, China

    7 h-index

    43 publications

    1.9K citations

1–8 of 436

Venues

  1. Journal of Controlled Release

    16 publications · 1.3K citations

    16

    h-index

  2. Biomaterials

    11 publications · 1K citations

    11

    h-index

  3. Molecular Pharmaceutics

    7 publications · 230 citations

    7

    h-index

  4. Bioconjugate Chemistry

    7 publications · 415 citations

    7

    h-index

  5. Journal of Materials Chemistry B

    7 publications · 622 citations

    7

    h-index

1–5