Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Features and development of <i>Coot</i>

Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 28.8K citations · Full text

Syntax, Model Validation, Engineering +15

<i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 24.1K citations · Full text

X-ray Crystallography, Structural Bioinformatics, Biomolecular Structure Prediction +14

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4K citations · Full text

Tumor Biology, Cancer-associated Idh1 Mutations, Oncogenic Agent +4

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

Richard A. Henderson, J.M. Baldwin, T.A. Ceska et al. · Journal of Molecular Biology · 1990 · 3K citations

High-resolution Electron Cryo-microscopy, Electron Microscopy, Biochemistry +8

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

Maofu Liao, Erhu Cao, David Julius et al. · Nature · 2013 · 1.7K citations · Full text

Biophysics, Trpv1 Ion Channel, Molecular Biology +5