Cryo-electron Microscopy

Cryo-Electron Microscopy is a structural biology technique that involves the rapid freezing of biological samples to preserve their natural conformation and the use of electron microscopy to determine high-resolution three-dimensional structures of macromolecular assemblies at near-atomic detail.

6.1K

Publications

528.5K

Citations

18.4K

Authors

2.8K

Institutions

Publications per year

2017–2026

2.4K

Variants

Cryo-em

Parents

Structural BiochemistryStructural BiologyStructural Biophysics

Children

Anisotropy CorrectionAtomic Model BuildingComputational Reconstruction AlgorithmsContrast Transfer Function CorrectionCorrelative Cryo-electron MicroscopyDetector CorrectionDose WeightingElectron Beam-induced DamageFlexible FittingFocused Classification

Publications

6.1K

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani, John L. Rubinstein, David J. Fleet et al. · Nature Methods · 2017 · 10.7K citations

Life Sciences, Bioinformatics, Biophysics +12

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Zheng, Eugene Palovcak, Jean‐Paul Armache et al. · Nature Methods · 2017 · 8.9K citations · Full text

Natural Sciences, Biophysics, Physics +12

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in <i>Phenix</i>

Dorothée Liebschner, Pavel V. Afonine, Matthew L. Baker et al. · Acta Crystallographica Section D Structural Biology · 2019 · 7.4K citations · Full text

Life Sciences, Biophysics, Computational Chemistry +16

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres · Journal of Structural Biology · 2012 · 6K citations · Full text

Life Sciences, Bioinformatics, Biophysics +16

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan, Yuanyuan Zhang, Yaning Li et al. · Science · 2020 · 5.6K citations · Full text

Life Sciences, Biology, Molecular Biology +16

1–5 of 6.1K

Authors

18.4K

WB
Wolfgang Baumeister
Max Planck Institute of Biochemistry, Germany
99 publications · 13.9K citations
61
h-index
WC
Wah Chiu
Baylor College of Medicine, United States
118 publications · 10.1K citations
60
h-index
SH
Sjors H. W. Scheres
MRC Laboratory of Molecular Biology, United Kingdom
70 publications · 28.4K citations
51
h-index
JF
Joachim Frank
Wadsworth Center, United States
71 publications · 8.2K citations
46
h-index
GJ
Grant J. Jensen
California Institute of Technology, United States
71 publications · 6.1K citations
45
h-index

1–5 of 18.4K

Institutions

2.8K

1–8 of 2.8K

Venues

Nature
141 publications · 34.9K citations
105
h-index
Proceedings of the National Academy of Sciences
PNAS · 288 publications · 29.3K citations
101
h-index
Journal of Structural Biology
431 publications · 45.6K citations
95
h-index
Science
120 publications · 35.8K citations
91
h-index
Nature Communications
319 publications · 25.3K citations
89
h-index

1–5