Matthew B. Boxer

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Life Sciences, Biochemistry, Oncology +17

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 825 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

Anju Singh, Sreedhar Venkannagari, Kyu Hee Oh et al. · ACS Chemical Biology · 2016 · 613 citations

Medicine, Oncology, Pharmacology +16

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 589 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +14

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Alan Merk, Alberto Bartesaghi, Soojay Banerjee et al. · Cell · 2016 · 519 citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +5