Sze Ham Chan

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

Monther Abu-Remaileh, Gregory A. Wyant, Choah Kim et al. · Science · 2017 · 658 citations · Full text

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 571 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Serine Synthesis +10

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

Mark R. Sullivan, Laura V. Danai, Caroline A. Lewis et al. · eLife · 2019 · 570 citations · Full text

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial

Sun Young Rha, Do‐Youn Oh, Patricio Yañez et al. · The Lancet Oncology · 2023 · 521 citations

Chemotherapy Versus Placebo, Gastrointestinal Oncology, Medicine +8

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Javier García‐Bermúdez, Lou Baudrier, Erol C. Bayraktar et al. · Nature · 2019 · 397 citations

Oxysterol, Biochemistry, Medicine +7