Systemic complement activation and complement gene analysis in enterohaemorrhagic<i>Escherichia coli</i>-associated paediatric haemolytic uraemic syndrome

Abstract

Complement activation at the acute phase of EHEC-HUS, indicated by increased levels of sC5b-9, predicts a poor outcome. Complement alterations appear to be more frequent in patients with EHEC-HUS than previously thought and are suspected to have a role in the severity of the disease.