Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors

Structure of the human smoothened receptor bound to an antitumour agent

Chong Wang, Huixian Wu, Vsevolod Katritch et al. · Nature · 2013 · 454 citations · Full text

Molecular Pharmacology, Drug Target, Receptor Bound +8

GDC-0449—A potent inhibitor of the hedgehog pathway

Kirk Robarge, Shirley A. Brunton, Georgette M. Castanedo et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 385 citations · Full text

Molecular Pharmacology, Signaling Pathway, Molecular Pathway +6

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang et al. · ACS Medicinal Chemistry Letters · 2010 · 325 citations · Full text

Selective Smoothened Antagonist, Chemoprevention Strategy, Novel Therapy +14

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

Grace Ka Yan Chan, Tracy Kleinheinz, David Peterson et al. · PLoS ONE · 2013 · 162 citations · Full text

Chemoprevention Strategy, Cell Proliferation, Cell Cycle +19

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

Michael J. Munchhof, Qifang Li, Andrei Shavnya et al. · ACS Medicinal Chemistry Letters · 2011 · 158 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Smoothened Inhibitor +20