Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)

Hao Zhang, Hongyi Zhao, Xiao-Xiao Xi, +6

European Journal of Medicinal Chemistry

MedicineCancer GrowthCell GrowthPharmacologyCell Biology +3

Discovery of potent small molecule PROTACs targeting mutant EGFR

Hongyi Zhao, Xueyan Yang, Hao Lei, +5

European Journal of Medicinal Chemistry

Tumor BiologyDrug TargetingMutant EgfrFibroblast Growth FactorMedicine +3

Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands

Hongyi Zhao, Haipeng Wang, Yu-Ze Mao, +7

Journal of Medicinal Chemistry

Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors

Hao Lei, Shu Fan, Hao Zhang, +6

European Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySubstituted 9H-purinesBiochemistryMedicine +7

Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity

Xiaoxiao Xie, Huan Li, Juan Wang, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceLow ToxicityBiochemistryMedicine +9

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs

Hao Zhang, Jin Wang, Ying Shen, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)MedicineOrganic Chemistry +3

Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors

Yuan‐Yuan Hei, Ying Shen, Jin Wang, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceMedicineNew Egfr InhibitorsPharmacotherapy +6

Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo

Xiaomeng Wang, Minhang Xin, Jing Xu, +4

European Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceAntitumor Activities EvaluationMedicinePharmacological Agent +8

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

Minhang Xin, Liandi Zhang, Feng Tang, +6

Bioorganic & Medicinal Chemistry

Diversity Oriented SynthesisDerivativesPathway InhibitorsBiochemistryMedicine +5

Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors

Yuan‐Yuan Hei, Minhang Xin, Hao Zhang, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntitumor Activity EvaluationMedicinePharmacological AgentNovel Pi3k Inhibitors +9