Michael J. Munchhof

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Chen Zhao, Alan Chen, Catriona Jamieson et al. · Nature · 2009 · 852 citations · Full text

Tumor Biology, Developmental Biology, Medicine +10

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Paul S. Changelian, Mark E. Flanagan, Douglas J. Ball et al. · Science · 2003 · 667 citations · Full text

Immunology, Cell Death, Immunotherapy +21

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer et al. · Nature Chemical Biology · 2015 · 533 citations

Vitro Potency, Signal Transduction, Medicine +10

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Mark E. Flanagan, Todd A. Blumenkopf, William H. Brissette et al. · Journal of Medicinal Chemistry · 2010 · 331 citations · Full text

Immunology, Janus Tyrosine Kinases, Immunotherapy +19

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

Michael J. Munchhof, Qifang Li, Andrei Shavnya et al. · ACS Medicinal Chemistry Letters · 2011 · 158 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Smoothened Inhibitor +20