Christina R. Majer

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 923 citations · Full text

Hematological Malignancy, Tumor Biology, Selective Killing +8

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 753 citations

Lymphoid Neoplasia, Medicine, Selective Inhibitor +8

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer et al. · Nature Chemical Biology · 2015 · 533 citations

Vitro Potency, Signal Transduction, Medicine +10

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

Sarah V. Gerhart, Wendy A. Kellner, Christine Thompson et al. · Scientific Reports · 2018 · 202 citations · Full text

Tumor Biology, Cellular Splicing, Prmt5 Inhibition +13

Chemogenetic Analysis of Human Protein Methyltransferases

Victoria M. Richon, Danielle Johnston, Christopher J. Sneeringer et al. · Chemical Biology & Drug Design · 2011 · 185 citations · Full text

Histone Modifications, Canonical Drosophila Su, Epigenetic Change +16