Grace Ka Yan Chan

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

Grace Ka Yan Chan, Tracy Kleinheinz, David Peterson et al. · PLoS ONE · 2013 · 162 citations · Full text

Chemoprevention Strategy, Cell Proliferation, Cell Cycle +19

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

Bryan Chan, Eileen M. Seward, Michael Lainchbury et al. · ACS Medicinal Chemistry Letters · 2021 · 42 citations · Full text

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Xiaojing Wang, Wesley Blackaby, Vivienne Allen et al. · Journal of Medicinal Chemistry · 2019 · 36 citations · Full text

Pim Kinases, Pharmacotherapy, Metronomic Chemotherapy +18

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

Huiyong Hu, Xiaojing Wang, Grace Ka Yan Chan et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 26 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Potent Pan-pim Inhibitors +6

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors

Dennis X. Hu, Snahel Patel, Huifen Chen et al. · Journal of Medicinal Chemistry · 2021 · 20 citations · Full text