Michael Lainchbury

A Protecting Group Free Synthesis of (±)-Neostenine via the [5 + 2] Photocycloaddition of Maleimides

Michael Lainchbury, Marcus I. Medley, Piers M. Taylor et al. · The Journal of Organic Chemistry · 2008 · 96 citations

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

Mike I. Walton, Paul D. Eve, Angela Hayes et al. · Clinical Cancer Research · 2012 · 92 citations · Full text

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

Mike I. Walton, Paul D. Eve, Angela Hayes et al. · Oncotarget · 2015 · 68 citations · Full text

Immunology, Ps296 Chk1, Pathology +19

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Emily J. Hanan, Charles Eigenbrot, Marian C. Bryan et al. · Journal of Medicinal Chemistry · 2014 · 61 citations · Full text

Broad Kinase Selectivity, Drug Target, Molecular Biology +21

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Robert A. Heald, Krista K. Bowman, Marian C. Bryan et al. · Journal of Medicinal Chemistry · 2015 · 55 citations · Full text