Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography.

Richard J. Lewis, Okram Mukherjee Singh, Clare V. Smith et al. · The EMBO Journal · 1996 · 331 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +5

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

Paul S. Charifson, Anne‐Laure Grillot, Trudy H. Grossman et al. · Journal of Medicinal Chemistry · 2008 · 225 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening

David A. Ostrov, J.A. Hernandez Prada, Patrick Corsino et al. · Antimicrobial Agents and Chemotherapy · 2007 · 201 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian Sherer, Kenneth G. Hull, Oluyinka Green et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Leslie W. Tari, Michael Trzoss, Daniel C. Bensen et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14