Concepedia

Structure-based Enzyme Targeting

Structure-Based Enzyme Targeting is a computational and biochemical approach that identifies and designs inhibitors or modulators of enzyme activity by leveraging the three-dimensional molecular structure of the target enzyme to guide precise interactions at its active or allosteric sites.

92

Publications

4.3K

Citations

787

Authors

276

Institutions

Publications per year

2017–2026

31

Parents

Publications

92

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

Guanghui Yang, Rui Zhou, Xuefei Guo et al. · Cell · 2020 · 195 citations

, , +16

Drug design of zinc-enzyme inhibitors functional, structural, and disease applications

Claudiu T. Supuran · HAL (Le Centre pour la Communication Scientifique Directe) · 2009 · 193 citations

, , +16

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7

Ilaria Lamberto, Xiaoxi Liu, Hyuk‐Soo Seo et al. · Cell chemical biology · 2017 · 188 citations · Full text

, , +14

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

Benjamin E. Turk, Robert Schwarzenbacher, Emily T Jarrell et al. · Nature Structural & Molecular Biology · 2003 · 179 citations

, , +16

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

Millicent Winner, Jason B. Meier, Swen Zierow et al. · Cancer Research · 2008 · 162 citations · Full text

, , +15

1–5 of 92

Authors

787

  1. SW
    Stephen W. White

    St. Jude Children's Research Hospital, United States

    3 publications · 136 citations

    3

    h-index

  2. RL
    Richard Lee

    Miami University, United States

    3 publications · 136 citations

    3

    h-index

  3. FD
    François Diederich

    ETH Zurich, Switzerland

    2 publications · 49 citations

    2

    h-index

  4. JC
    Jeffrey C. Dyason

    Griffith University, Australia

    2 publications · 176 citations

    2

    h-index

  5. OA
    Ole A. Andersen

    University of Dundee, United Kingdom

    2 publications · 120 citations

    2

    h-index

1–5 of 787

Institutions

276

  1. Harvard University

    Cambridge, United States

    3 h-index

    15 publications

    2.5K citations

  2. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    13 publications

    785 citations

  3. St. Jude Children's Research Hospital

    Memphis, United States

    3 h-index

    19 publications

    762 citations

  4. University of Tennessee Health Science Center

    Memphis, United States

    3 h-index

    10 publications

    641 citations

  5. Northwestern University

    Evanston, United States

    3 h-index

    15 publications

    632 citations

  6. Griffith University

    Brisbane, Australia

    3 h-index

    17 publications

    1K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    83 citations

  8. University of Warwick

    Coventry, United Kingdom

    2 h-index

    9 publications

    789 citations

1–8 of 276

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    9 publications · 370 citations

    9

    h-index

  2. Journal of Medicinal Chemistry

    9 publications · 381 citations

    9

    h-index

  3. Bioorganic & Medicinal Chemistry

    4 publications · 83 citations

    4

    h-index

  4. Biochemistry

    4 publications · 110 citations

    4

    h-index

  5. Nature Communications

    3 publications · 232 citations

    3

    h-index

1–5