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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Medicinal ChemistryDrug TargetDna Gyrase BBiochemistryNatural SciencesTopoisomerase IvRational Drug DesignMolecular BiologyDrug DevelopmentMedicineEnzymatic ModificationPyrrolopyrimidine InhibitorsDrug Discovery