Bryan P. Kwan

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Leslie W. Tari, Michael Trzoss, Daniel C. Bensen et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Leslie W. Tari, Xiaoming Li, Michael Trzoss et al. · PLoS ONE · 2013 · 104 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Micheal Trzoss, Daniel C. Bensen, Xiaoming Li et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 81 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines

Thanh Lam, M.T. Hilgers, Mark L. Cunningham et al. · Journal of Medicinal Chemistry · 2014 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

Xiaoming Li, M.T. Hilgers, Mark L. Cunningham et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13