Christopher J. Creighton

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Leslie W. Tari, Michael Trzoss, Daniel C. Bensen et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 118 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Micheal Trzoss, Daniel C. Bensen, Xiaoming Li et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 81 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis of an Eight-Membered Cyclic Pseudo-Dipeptide Using Ring Closing Metathesis

Christopher J. Creighton, Allen B. Reitz · Organic Letters · 2001 · 72 citations

Natural Sciences, Chemistry, Medicinal Chemistry +17

Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis

Christopher J. Creighton, Gregory C. Leo, Yanming Du et al. · Bioorganic & Medicinal Chemistry · 2004 · 56 citations

Natural Sciences, Chemistry, Medicinal Chemistry +16

Scale-up Synthesis of (<i>R</i>)- and (<i>S</i>)-<i>N</i>-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made α- and β-Amino Acids in an Enantiomerically Pure Form

Todd T. Romoff, Andrew B. Palmer, Noel Mansour et al. · Organic Process Research & Development · 2017 · 45 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +10