Concepedia

Fragment-based Discovery

Fragment-Based Discovery is a drug discovery approach that identifies low molecular weight chemical fragments binding weakly but efficiently to target proteins, which are subsequently optimized into high-affinity ligands through iterative structural and medicinal chemistry refinement.

768

Publications

38.1K

Citations

4.8K

Authors

978

Institutions

Publications per year

2017–2026

308

Parents

Publications

768

RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Xiao Qing Lewell, Duncan B. Judd, Michael M. Hann · Journal of Chemical Information and Computer Sciences · 1998 · 701 citations

, , +13

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Christopher G. Parker, Andrea Galmozzi, Yujia Wang et al. · Cell · 2017 · 462 citations · Full text

, , +16

Fragment-based identification of druggable ‘hot spots’ of proteins using Fourier domain correlation techniques

Ryan Brenke, Dima Kozakov, Gwo‐Yu Chuang et al. · Bioinformatics · 2009 · 457 citations · Full text

, , +17

Fragment-Based Lead Discovery Using X-ray Crystallography

Michael J. Hartshorn, Christopher W. Murray, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 423 citations

, , +16

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Steven Howard, Valério Berdini, John A. Boulstridge et al. · Journal of Medicinal Chemistry · 2008 · 331 citations · Full text

, , +14

1–5 of 768

Authors

4.8K

  1. CA
    Chris Abell

    University of Cambridge, United Kingdom

    24 publications · 1.5K citations

    21

    h-index

  2. TL
    Tom L. Blundell

    University of Cambridge, United Kingdom

    19 publications · 878 citations

    16

    h-index

  3. CW
    Christopher W. Murray

    Proteus (United Kingdom), United Kingdom

    15 publications · 1.9K citations

    15

    h-index

  4. RE
    Roderick E. Hubbard

    University of York, United Kingdom

    14 publications · 714 citations

    14

    h-index

  5. IJ
    Iwan J. P. de Esch

    Vrije Universiteit Amsterdam, Netherlands

    12 publications · 695 citations

    12

    h-index

1–5 of 4.8K

Institutions

978

  1. University of Cambridge

    Cambridge, United Kingdom

    31 h-index

    241 publications

    12.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    149 publications

    6K citations

  3. University of Oxford

    Oxford, United Kingdom

    20 h-index

    105 publications

    5.6K citations

  4. Granta Design (United Kingdom)

    Cambridge, United Kingdom

    17 h-index

    97 publications

    6K citations

  5. Novartis (Switzerland)

    Basel, Switzerland

    15 h-index

    120 publications

    6.2K citations

  6. University of California, San Francisco

    San Francisco, United States

    14 h-index

    62 publications

    2.4K citations

  7. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    13 h-index

    49 publications

    3K citations

  8. Université Claude Bernard Lyon 1

    Villeurbanne, France

    12 h-index

    40 publications

    1.5K citations

1–8 of 978

Venues

  1. Journal of Medicinal Chemistry

    158 publications · 11.5K citations

    64

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 40 publications · 1.4K citations

    25

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    34 publications · 1.4K citations

    24

    h-index

  4. ACS Medicinal Chemistry Letters

    28 publications · 1.2K citations

    21

    h-index

  5. Journal of the American Chemical Society

    JACS · 20 publications · 1.8K citations

    20

    h-index

1–5