Concepedia

Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry

Richard Conroy, David J. Miller, John Mills, John G. Montana, Parminder K. Pooni, Graham A. Showell, Louise Walsh, J.B.H. Warneck

Bioorganic & Medicinal Chemistry Letters · 2006 · 66 citations · 6 references

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New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

Patrick Y. S. Lam, Charles G. Clark, Simon Saubern et al. · Tetrahedron Letters · 1998 · 1.1K citations

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

A M Badger, Jeremy N. Bradbeer, Bartholomew J. Votta et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 499 citations

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Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate

John R. Regan, Steffen Breitfelder, Pier F. Cirillo et al. · Journal of Medicinal Chemistry · 2002 · 350 citations · Full text

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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

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Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Adrian L. Gill, Martyn Frederickson, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 188 citations · Full text

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