John W. Butcher

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Steven J. Harper, John A. McCauley, Michael T. Rudd et al. · ACS Medicinal Chemistry Letters · 2012 · 201 citations · Full text

Immunology, Molecular Biology, Pharmacotherapy +19

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

Immunology, Pharmacotherapy, Chemical Biology +17

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

John A. McCauley, Charles McIntyre, Michael T. Rudd et al. · Journal of Medicinal Chemistry · 2010 · 176 citations

Immunology, Antiviral Drug, Medicinal Chemistry +17

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Nigel J. Liverton, M. Katharine Holloway, John A. McCauley et al. · Journal of the American Chemical Society · 2008 · 134 citations

Molecular Docking, Medicinal Chemistry, Initial Compounds +14

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current <i>I</i>_Ks by (<i>R</i>)-2-(2,4- Trifluoromethyl)-<i>N</i>-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-3-yl]acetamide

Harold G. Selnick, Nigel J. Liverton, John J. Baldwin et al. · Journal of Medicinal Chemistry · 1997 · 94 citations · Full text

Molecular Pharmacology, Cardiac Muscle, Selective Blockade +15