Christopher F. Claiborne

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Novel Therapy, Medicine, New Approach +9

Total synthesis of taxol

K. C. Nicolaou, Zhen Yang, Jimei Liu et al. · Nature · 1994 · 1.1K citations

Pharmacology, Organic Chemistry, Synthetic Chemistry +1

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 457 citations · Full text

Protein Chemistry, Nedd8-amp Mimetic, Protein Function +7

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze et al. · Proceedings of the National Academy of Sciences · 2007 · 413 citations · Full text

Tumor Biology, Active Small-molecule Inhibitor, Antitumor Activity +15

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty et al. · Clinical Cancer Research · 2011 · 298 citations