Patrick Y. S. Lam

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

Patrick Y. S. Lam, Charles G. Clark, Simon Saubern et al. · Tetrahedron Letters · 1998 · 1K citations

Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 834 citations

Combinatorial Chemistry, Bioorganic Chemistry, Nonpeptide Cyclic Ureas +18

Copper-Promoted Carbon-Heteroatom Bond Cross-Coupling with Boronic Acids and Derivatives

Jennifer X. Qiao, Patrick Y. S. Lam · Synthesis · 2010 · 550 citations

Inorganic Chemistry, Chemical Engineering, Cross-coupling Reaction +8

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1<i>H</i>-pyrazolo[3,4-<i>c</i>]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Stephanie C. Koch et al. · Journal of Medicinal Chemistry · 2007 · 391 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Primary Aniline +15

Pax3 modulates expression of the c-Met receptor during limb muscle development.

Jonathan A. Epstein, David N. Shapiro, Jane Cheng et al. · Proceedings of the National Academy of Sciences · 1996 · 359 citations · Full text

Muscle Function, Cellular Physiology, Muscle Physiology +21