Martyn Frederickson

Fragment-Based Lead Discovery Using X-ray Crystallography

Michael J. Hartshorn, Christopher W. Murray, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 423 citations

Pharmacy, Chemistry, Medicinal Chemistry +16

Optically active isoxazolidines via asymmetric cycloaddition reactions of nitrones with alkenes: applications in organic synthesis

Martyn Frederickson · Tetrahedron · 1997 · 412 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 263 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Adrian L. Gill, Martyn Frederickson, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 188 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17