Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

A model for p53-induced apoptosis

Kornélia Polyák, Yong Xia, Jay L. Zweíer et al. · Nature · 1997 · 2.5K citations

Life Sciences, Cell Biology, Molecular Biology +12

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Bruce Grasberger, Tianbao Lu, Carsten J. Schubert et al. · Journal of Medicinal Chemistry · 2005 · 427 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

Angelika Böttger, Volker Böttger, Alison Sparks et al. · Current Biology · 1997 · 363 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +11

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 167 citations

Medicine, Medicinal Chemistry, Pharmacology +11