Small peptides activate the latent sequence-specific DNA binding function of p53

Ted R. Hupp, Alison Sparks, David P. Lane

Cell

Protein FunctionLatent Sequence-specific DnaPeptide LibrarySmall PeptidesMolecular Biology +4

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

Angelika Böttger, Volker Böttger, Alison Sparks, +3

Current Biology

P53 ResponseMedicineMolecular BiologyTumor SuppressorMolecular Docking +2

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Lauren Stevenson, Alison Sparks, Nerea Allende-Vega, +3

The EMBO Journal

Molecular BiologyTumor SuppressorP53 PathwayCancer GeneticsMedicine +2

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

Carol Midgley, Joana Desterro, Mark K. Saville, +4

Oncogene

Mdm2-dependent UbiquitinationN-terminal P14arf PeptideMedicineMolecular BiologyTumor Suppressor +4

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

Steven M. Picksley, B Vojtĕsek, Alison Sparks, +1

PubMed

Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

Christine Blattner, Alison Sparks, David P. Lane

Molecular and Cellular Biology

Dna DamageGeneticsApoptosisCell DeathMdm2-dependent Degradation +17

Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

Saurabh Dayal, Alison Sparks, Jimmy Jacob, +3

Journal of Biological Chemistry

Transcriptional RegulationUnanchored PolyubiquitinUbiquitinated P53P53 UbiquitinationDeubiquitinating Enzyme Usp5 +13

Cell type-specific responses of human cells to inhibition of replication licensing

Sathyavageeswaran Shreeram, Alison Sparks, David P. Lane, +1

Oncogene

Human CellCell RegulationCell DivisionHuman CellsMedicine +8

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo

Mark K. Saville, Alison Sparks, Dimitris P. Xirodimas, +5

Journal of Biological Chemistry

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

Sonia Laı́n, Carol Midgley, Alison Sparks, +2

Experimental Cell Research

P53 ResponseNuclear ExportCell RegulationNatural SciencesMolecular Biology +3