An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences · 1992 · 4.9K citations

Viral Replication, Molecular Regulation, Immunology +20

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Tumor Biology, Medicine, Rapid Degradation +6

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Tumor Biology, Tumor Suppressor, Medicine +3

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Oncogenic Agent, Medicine, Molecular Biology +9

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Wei Gu, R G Roeder · Cell · 1997 · 2.5K citations · Full text

P53 C-terminal Domain, Molecular Biology, Molecular Basis +4