Kristi Leonard

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Robert H. Scannevin, Richard Alexander, Tara Mezzasalma Haarlander et al. · Journal of Biological Chemistry · 2017 · 171 citations · Full text

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation <i>in vitro</i> and sensitize tumors to doxorubicin <i>in vivo</i>

Holly K. Koblish, Shuyuan Zhao, Carol F. Franks et al. · Molecular Cancer Therapeutics · 2006 · 162 citations · Full text

P53 Interaction, Chemoprevention Strategy, P53 Complex +18

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo et al. · Scientific Reports · 2016 · 74 citations · Full text

Immunology, Immune Regulation, Innate Immunity +26

Design, Synthesis, and Biological Evaluation of Novel Potent and Selective α_vβ₃/α_vβ₅ Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core

Juan Marugán, Carl L. Manthey, Beth Anaclerio et al. · Journal of Medicinal Chemistry · 2005 · 68 citations · Full text

Improved Bioavailability, Pharmaceutical Science, Selective Alpha +17

Synthesis and Evaluation of Chalcogenopyrylium Dyes as Potential Sensitizers for the Photodynamic Therapy of Cancer

Kristi Leonard, Marina I. Nelen, Todd P. Simard et al. · Journal of Medicinal Chemistry · 1999 · 65 citations