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High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate

Michela Zolli‐Juran, Jonathan Cechetto, Rebecca Hartlen, Denis M. Daigle, Eric D. Brown

Bioorganic & Medicinal Chemistry Letters · 2003 · 69 citations · 10 references

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References

10

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

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The Biochemistry of Folic Acid and Related Pteridines.

Annals of Internal Medicine · 1970 · 1K citations

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Loop and Subdomain Movements in the Mechanism of <i>Escherichia coli </i>Dihydrofolate Reductase:  Crystallographic Evidence<sup>,</sup>

M.R. Sawaya, Joseph Kraut · Biochemistry · 1997 · 666 citations

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Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase

Brian L. Hillcoat, Peter F. Nixon, Raymond L. Blakley · Analytical Biochemistry · 1967 · 236 citations

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Inhibition of dihydrofolate reductase: effect of NADPH on the selectivity and affinity of diaminobenzylpyrimidines

David P. Baccanari, Susan M. Daluge, R. W. King · Biochemistry · 1982 · 100 citations

, , +10