Denis M. Daigle

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Bin Liu, Robert E. Lee Trout, Guo‐Hua Chu et al. · Journal of Medicinal Chemistry · 2019 · 298 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in <i>Enterobacterales</i> and Pseudomonas aeruginosa

Jodie C. Hamrick, Jean‐Denis Docquier, Tsuyoshi Uehara et al. · Antimicrobial Agents and Chemotherapy · 2019 · 213 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

<i>mexEF-oprN</i> Multidrug Efflux Operon of <i>Pseudomonas aeruginosa</i> : Regulation by the MexT Activator in Response to Nitrosative Stress and Chloramphenicol

Hossam Fetar, C. M. Gilmour, Rachael Klinoski et al. · Antimicrobial Agents and Chemotherapy · 2010 · 136 citations · Full text

Life Sciences, Genetics, Microbiology +17

Prodigious substrate specificity of AAC(6′)-APH(2′'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci

Denis M. Daigle, Donald W. Hughes, Gerard D. Wright · Chemistry & Biology · 1999 · 109 citations · Full text

Life Sciences, Microbiology, Antimicrobial Resistance +13

Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors

Denis M. Daigle, Geoffrey A. McKay, Gerard D. Wright · Journal of Biological Chemistry · 1997 · 104 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16