Concepedia

Lead Enzyme Discovery

Lead Enzyme Discovery is a scholarly contribution within the domain of biocatalyst screening that identifies and characterizes novel enzymes with optimized functional properties for targeted biochemical transformations, distinguishing itself by providing foundational methodologies, frameworks, or empirical data that guide subsequent enzyme engineering and application efforts.

154

Publications

7.2K

Citations

1.2K

Authors

294

Institutions

Publications per year

2017–2026

44

Parents

Publications

154

LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

Hans-Joachim B�hm · Journal of Computer-Aided Molecular Design · 1992 · 459 citations

, , +15

Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Philip J. Hajduk, George S. Sheppard, David G. Nettesheim et al. · Journal of the American Chemical Society · 1997 · 317 citations

, , +13

A cell-free framework for rapid biosynthetic pathway prototyping and enzyme discovery

Ashty S. Karim, Michael C. Jewett · Metabolic Engineering · 2016 · 261 citations

, , +16

β‐Lactones as Privileged Structures for the Active‐Site Labeling of Versatile Bacterial Enzyme Classes

Thomas Böttcher, Stephan A. Sieber · Angewandte Chemie International Edition · 2008 · 183 citations

, , +17

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Anup Aggarwal, Maloy Kumar Parai, N.D. Shetty et al. · Cell · 2017 · 182 citations · Full text

, , +12

1–5 of 154

Authors

1.2K

  1. AC
    Amy C. Anderson

    University of Connecticut, United States

    4 publications · 124 citations

    4

    h-index

  2. GK
    G. Klebe

    Philipps University of Marburg, Germany

    3 publications · 106 citations

    3

    h-index

  3. DB
    Daniela Barlocco

    University of Milan, Italy

    3 publications · 94 citations

    3

    h-index

  4. DB
    David B. Bolstad

    University of Connecticut, United States

    3 publications · 106 citations

    3

    h-index

  5. DL
    Dennis L. Wright

    University of Connecticut, United States

    3 publications · 106 citations

    3

    h-index

1–5 of 1.2K

Institutions

294

  1. Scripps Research Institute

    San Diego, United States

    5 h-index

    12 publications

    531 citations

  2. University of Oxford

    Oxford, United Kingdom

    4 h-index

    27 publications

    1K citations

  3. University of Naples Federico II

    Naples, Italy

    4 h-index

    20 publications

    566 citations

  4. University of Milan

    Milan, Italy

    4 h-index

    27 publications

    777 citations

  5. University of Connecticut

    Storrs, United States

    4 h-index

    21 publications

    737 citations

  6. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    12 publications

    466 citations

  7. Harvard University

    Cambridge, United States

    4 h-index

    13 publications

    1.1K citations

  8. University of Pisa

    Pisa, Italy

    3 h-index

    8 publications

    286 citations

1–8 of 294

Venues

  1. Journal of Medicinal Chemistry

    29 publications · 1.6K citations

    24

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    8 publications · 216 citations

    8

    h-index

  3. ChemMedChem

    6 publications · 132 citations

    6

    h-index

  4. Bioorganic & Medicinal Chemistry

    4 publications · 162 citations

    4

    h-index

  5. Angewandte Chemie International Edition

    4 publications · 301 citations

    4

    h-index

1–5