Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Anup Aggarwal, Maloy Kumar Parai, N.D. Shetty, +27

Cell

An Antibacterial β‐Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis

Johannes Lehmann, Tan‐Yun Cheng, Anup Aggarwal, +9

Angewandte Chemie International Edition

Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design

Jamie Jarusiewicz, Satoshi Yoshimura, Anand Mayasundari, +13

ACS Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +12

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, +32

Nature Communications

Tumor BiologyProtein FunctionBroad RangeAntiproliferative ActivityMedicine +13

Structural basis of BAK activation in mitochondrial apoptosis initiation

Geetika Singh, Cristina D. Guibao, J. Seetharaman, +6

Nature Communications

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Caroline Wilson, Peter C. Ray, Fabio Zuccotto, +37

Journal of Medicinal Chemistry

Crystal structure of calcium dodecin (Rv0379), from <i>Mycobacterium tuberculosis</i> with a unique calcium‐binding site

A. Arockiasamy, Anup Aggarwal, Christos G. Savva, +2

Protein Science

Crystal StructureProtein AssemblyBiomolecular Structure PredictionStructural BioinformaticsMolecular Biology +15

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Martin Steger, Gisele Nishiguchi, Qiong Wu, +17

Nature Communications

<i>Mycobacterium tuberculosis</i>acyl carrier protein synthase adopts two different pH-dependent structural conformations

Kuppan Gokulan, Anup Aggarwal, Lance W. Shipman, +2

Acta Crystallographica Section D Biological Crystallography

Electron DensityProtein AssemblyBiochemistryNatural SciencesMycobacterium Tuberculosis +10

Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs

Marisa Actis, Joel O. Cresser-Brown, Elizabeth A. Caine, +22

Journal of Medicinal Chemistry