George S. Sheppard

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

H Zhang, J Chen, Sajid Khan Tahir et al. · Cell Death and Disease · 2015 · 427 citations · Full text

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Emily J. Faivre, Keith F. McDaniel, Daniel H. Albert et al. · Nature · 2020 · 389 citations

Bd2 Bromodomain, Medicine, Natural Sciences +9

Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Philip J. Hajduk, George S. Sheppard, David G. Nettesheim et al. · Journal of the American Chemical Society · 1997 · 316 citations

Diastereoselective aldol reactions using .beta.-keto imide derived enolates. A versatile approach to the assemblage of polypropionate systems

David A. Evans, J. Stephen Clark, Rainer Metternich et al. · Journal of the American Chemical Society · 1990 · 259 citations

Polypropionate Systems, Engineering, Biochemistry +12

Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity

Milan Bruncko, Le Wang, George S. Sheppard et al. · Journal of Medicinal Chemistry · 2015 · 150 citations · Full text

Drug Target, Mcl-1 Inhibitors, High Throughput +23