Concepedia

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Cristina C. Clement, Yanlong Kang, Yuhong She, Nian Wu,

Nature Chemical Biology · 2007 · 156 citations · 31 references

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31

Negative regulation of the Apaf-1 apoptosome by Hsp70

Ayman Saleh, Srinivasa M. Srinivasula, Levent Balkir et al. · Nature Cell Biology · 2000 · 820 citations

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Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

Santos A. Susín, Hans Kristian Lorenzo, Naoufal Zamzami et al. · The Journal of Experimental Medicine · 1999 · 719 citations · Full text

, , +17

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Andrea Basso, David B. Solit, Gabriela Chiosis et al. · Journal of Biological Chemistry · 2002 · 626 citations · Full text

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Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90

Pramod S. Pandey, Ayman Saleh, Atsuko Nakazawa et al. · The EMBO Journal · 2000 · 557 citations · Full text

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Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

Jesper Nylandsted, Mikkel Rohde, Karsten Brand et al. · Proceedings of the National Academy of Sciences · 2000 · 390 citations

, , +17