Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Jesper Nylandsted, Mads Gyrd‐Hansen, Agnieszka Danielewicz, +7

The Journal of Experimental Medicine

ApoptosisImmunologyCell DeathMolecular BiologyHsp70 Depletion +16

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Thomas Kirkegaard, Anke G. Roth, Nikolaj H.T. Petersen, +9

Nature

Protein FunctionLysosomal Storage DiseaseAutophagyMolecular BiologyMedicine +2

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Mikkel Rohde, Mads Daugaard, Mette Hartvig Jensen, +3

Genes & Development

Distinct MechanismsMolecular BiologyCancer BiologyHeat-shock Protein 70Tumor Biology +15

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

Jesper Nylandsted, Mikkel Rohde, Karsten Brand, +3

Proceedings of the National Academy of Sciences

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

Nikolaj H.T. Petersen, Ole Dines Olsen, Line Groth‐Pedersen, +15

Cancer Cell

MitophagySignal TransductionBiochemistryApoptosisAutophagy +9

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Jyoti K. Jaiswal, Stine Lauritzen Sønder, Luana Scheffer, +6

Nature Communications

Tumor BiologyMedicineInvasive Cancer CellsMembrane SystemRadiation Oncology +3

Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine

Line Groth‐Pedersen, Marie S. Ostenfeld, Maria Høyer-Hansen, +2

Cancer Research

Heat Shock Protein 70 Is Required for the Survival of Cancer Cells

Jesper Nylandsted, Karsten Brand, Marja Jäättelä

Annals of the New York Academy of Sciences

Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair

Theresa Louise Boye, Kenji Maeda, Weria Pezeshkian, +5

Nature Communications

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Sonia Hernández‐Tiedra, Gemma Fabriàs, David Dávila, +23

Autophagy