BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas, +11

Nature

Signal TransductionBraf MutationGenetic DisorderMedicineGenetics +4

Identification of Potent Water Soluble Purine-Scaffold Inhibitors of the Heat Shock Protein 90

Huazhong He, Danuta Zatorska, Joungnam Kim, +7

Journal of Medicinal Chemistry

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Anna Rodina, Maria Vilenchik, Kamalika Moulick, +15

Nature Chemical Biology

Major InhibitorMedicineApoptosisCell DeathAnti-cancer Agent +7

Pulsatile Administration of the Epidermal Growth Factor Receptor Inhibitor Gefitinib Is Significantly More Effective than Continuous Dosing for Sensitizing Tumors to Paclitaxel

David B. Solit, Yuhong She, Jose Lobo, +4

Clinical Cancer Research

Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.

Monica Motwani, Christoph P. Jung, Francis M. Sirotnak, +4

PubMed

Tumor BiologyTumor RegressionOncologyChemoprevention StrategyMedicine +12

Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

Eunice S. Wang, Owen A. O’Connor, Yuhong She, +3

Leukemia & lymphoma/Leukemia and lymphoma

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Mona D. Lee, Yuhong She, Michael J. Soskis, +9

Journal of Clinical Investigation

Bioorganic ChemistryAntibiotic AdjuvantMolecular BiologyAntimicrobial ChemotherapyChemical Biology +19

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Mona D. Lee, Yuhong She, Michael J. Soskis, +9

Journal of Clinical Investigation

Bioorganic ChemistryAntibiotic AdjuvantMolecular BiologyAntimicrobial ChemotherapyChemical Biology +19

Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells.

Monica Motwani, Carina Rizzo, Francis M. Sirotnak, +2

PubMed

Tumor BiologyMolecular PharmacologyOncologyDocetaxel EffectGastrointestinal Oncology +13

Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro

Hong Lin, Yuhong She, Barrie R. Cassileth, +2

International Immunopharmacology

Bone Marrow FailureMedicineHematologyImmunologyCell Death +4