Francis M. Sirotnak

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

Francis M. Sirotnak, Maureen F. Zakowski, V.A. Miller et al. · PubMed · 2000 · 762 citations

Medicine, Oncology, Pharmacology +15

Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium

Christy D. Chancy, Ramesh Kekuda, Wei Huang et al. · Journal of Biological Chemistry · 2000 · 152 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

Francis M. Sirotnak, Joseph I. DeGraw, D. M. Moccio et al. · Cancer Chemotherapy and Pharmacology · 1984 · 143 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

New folate analogs of the 10-deaza-aminopterin series

Francis M. Sirotnak, Joseph I. DeGraw, Franz A. Schmid et al. · Cancer Chemotherapy and Pharmacology · 1984 · 137 citations

Pharmacy, Biochemistry, Medicinal Chemistry +9

Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency

Hamid M. Said, Nabendu Sekhar Chatterjee, Riaz ul Haq et al. · American Journal of Physiology-Cell Physiology · 2000 · 136 citations

Agriculture, Nutrition, Nutritional Sciences +17