New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

New folate analogs of the 10-deaza-aminopterin series

Francis M. Sirotnak, Joseph I. DeGraw, Franz A. Schmid et al. · Cancer Chemotherapy and Pharmacology · 1984 · 137 citations

Pharmacy, Biochemistry, Medicinal Chemistry +9

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.

Richard G. Poser, Francis M. Sirotnak, Paul L. Chello · PubMed · 1981 · 85 citations

Medicine, Oncology, Pharmacology +12

The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.

Stephen C. Margolis, Frederick S. Philips, Stephen S. Sternberg · PubMed · 1971 · 79 citations

Medicine, Biochemistry, Pharmacology +9

Steady-state enzyme kinetics with high-affinity substrates or inhibitors. A statistical treatment of dose–response curves

Peter J. F. Henderson · Biochemical Journal · 1973 · 74 citations · Full text

Life Sciences, Biochemistry, Chemical Kinetics +14

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

F. M. Sirotnak, Ruth C. Donsbach · PubMed · 1976 · 64 citations

Medicine, Pharmacokinetics, Pharmacology +15