F. M. Sirotnak

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

F. M. Sirotnak, D. M. Moccio, L. E. Kelleher et al. · PubMed · 1981 · 189 citations

Kinetic Properties, Mixed-phenotype Acute Leukemia, Resistant Phenotypes +19

Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

Eunice S. Wang, Owen A. O’Connor, Yuhong She et al. · Leukemia & lymphoma/Leukemia and lymphoma · 2003 · 113 citations

New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

Franz A. Schmid, F. M. Sirotnak, Glenys M. Otter et al. · PubMed · 1985 · 69 citations

Immunology, Pharmacotherapy, Human Tumor Xenografts +19

The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.

Yuhong She, Fei Lee, Jing Chen et al. · PubMed · 2003 · 68 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

F. M. Sirotnak, Ruth C. Donsbach · PubMed · 1976 · 64 citations

Hematological Malignancy, Tumor Biology, Kinetic Correlates +14