Glenys M. Otter

New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

Franz A. Schmid, F. M. Sirotnak, Glenys M. Otter et al. · PubMed · 1985 · 69 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.

Adam P. Dicker, Mark Waltham, Matthias Volkenandt et al. · Proceedings of the National Academy of Sciences · 1993 · 41 citations

Medicine, Oncology, Pharmacology +14

Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro

Ting‐Chao Chou, Glenys M. Otter, Francis M. Sirotnak · Cancer Chemotherapy and Pharmacology · 1995 · 34 citations

Medicine, Oncology, Pharmacology +12

Studies on analogs of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain

James R. Piper, Cheryl A. Johnson, Joseph A. Maddry et al. · Journal of Medicinal Chemistry · 1993 · 30 citations · Full text

Pharmacy, Chemistry, Pharmacology +6

Chemical synthesis and biological activities of 5-deazaaminopterin analogs bearing substituent(s) at the 5- and/or 7-position(s)

Tsann Long Su, Jai Tung Huang, Ting‐Chao Chou et al. · Journal of Medicinal Chemistry · 1988 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7