Fei Lee

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

Michael J. Giffin, Keegan S. Cooke, Edward K. Lobenhofer et al. · Clinical Cancer Research · 2020 · 220 citations · Full text

Studies with CWR22 xenografts in nude mice suggest that ZD1839 may have a role in the treatment of both androgen-dependent and androgen-independent human prostate cancer.

Francis M. Sirotnak, Yohung She, Fei Lee et al. · PubMed · 2002 · 103 citations

Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures

Kexue Li, Lawrence R. McGee, Ben Fisher et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 71 citations · Full text

Structure–activity Relationship, Nf-κb-inducing Kinase, Biochemistry +9

The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.

Yuhong She, Fei Lee, Jing Chen et al. · PubMed · 2003 · 68 citations

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

Jinsong Liu, Athena Sudom, Xiaoshan Min et al. · Journal of Biological Chemistry · 2012 · 56 citations · Full text