Paul L. Chello

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.

Richard G. Poser, Francis M. Sirotnak, Paul L. Chello · PubMed · 1981 · 85 citations

Polyglutamate Synthesis, Polyglutamate Formation, Methotrexate Polyglutamates +15

5-Methyl-5,6,7,8-tetrahydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with methionine synthetase from bovine brain

James K. Coward, Paul L. Chello, Arlene R. Cashmore et al. · Biochemistry · 1975 · 85 citations

Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II.

Paul L. Chello, Joseph R. Bertino · PubMed · 1973 · 81 citations

Vitamin Nutrition, Hematological Malignancy, Nutrient Physiology +15

Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

Francis M. Sirotnak, Paul L. Chello, D. M. Moccio et al. · Biochemical Pharmacology · 1979 · 71 citations

Medicinal Chemistry, Carbon 6, Biochemistry +10

Syntheses of .alpha.- and .gamma.-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism

James R. Piper, John A. Montgomery, Francis M. Sirotnak et al. · Journal of Medicinal Chemistry · 1982 · 65 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, .Gamma.-substituted Amides +15