Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

Life Sciences, Biochemistry, Biochemical Pharmacology +15

The Biochemistry of Folic Acid and Related Pteridines.

Annals of Internal Medicine · 1970 · 1K citations

Life Sciences, Biochemistry, Nutritional Sciences +14

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

I. David Goldman · Annals of the New York Academy of Sciences · 1971 · 285 citations

Engineering, Biochemistry, Biophysics +10

Recent advances in the chemotherapy of metastatic osteogenic sarcoma

Norman Jaffe · Cancer · 1972 · 277 citations · Full text

Medicine, Oncology, Pharmacotherapy +16

New Approaches to Cancer Chemotherapy with Methotrexate

Howard L. Bleich, Emily S. Boro, E Frei et al. · New England Journal of Medicine · 1975 · 232 citations

Medicine, Oncology, Pharmacology +16