Arlene R. Cashmore

Studies on the Inhibition of Dihydrofolate Reductase by the Folate Antagonists

Joseph R. Bertino, Barbara A. Booth, Allan L. Bieber et al. · Journal of Biological Chemistry · 1964 · 176 citations · Full text

Biochemistry, Medicine, Secondary Metabolite +7

Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro

Barton A. Kamen, Beatrice Eibl, Arlene R. Cashmore et al. · Biochemical Pharmacology · 1984 · 112 citations

Hematological Malignancy, Medicinal Chemistry, Oncology +10

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.

G Pizzorno, Enrico Mini, Marcella Coronnello et al. · PubMed · 1988 · 110 citations

Impaired Polyglutamylation, Methotrexate Polyglutamate Synthesis, Resistant Sublines +13

7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources

James K. Coward, K. N. Parameswaran, Arlene R. Cashmore et al. · Biochemistry · 1974 · 94 citations

Mammalian Sources, Altmetric Attention Score, 7,8-Dihydropteroyl Oligo-γ-l-glutamates +18

5-Methyl-5,6,7,8-tetrahydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with methionine synthetase from bovine brain

James K. Coward, Paul L. Chello, Arlene R. Cashmore et al. · Biochemistry · 1975 · 85 citations