Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.

G Pizzorno, Enrico Mini, Marcella Coronnello, +7

PubMed

Impaired PolyglutamylationMethotrexate Polyglutamate SynthesisResistant SublinesHematological MalignancyBiochemistry +11

Percutaneous hepatic vein isolation and high-dose hepatic arterial infusion chemotherapy for unresectable liver tumors.

T.S. Ravikumar, G Pizzorno, William Bodden, +6

Journal of Clinical Oncology

Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.

Menghan Liu, Deliang Cao, Rosalind L. Russell, +2

PubMed

PathologyEscherichia ColiChemical BiologyTumor BiologyProtein Expression +16

Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter

J C Schwab, Mohammed Afifi Afifi, G Pizzorno, +2

Molecular and Biochemical Parasitology

Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.

G Pizzorno, Barbara A. Moroson, Arlene R. Cashmore, +6

PubMed

Chemoprevention StrategyCell Culture SystemsCancer BiologyTumor BiologyDrug Resistance +15

Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer.

John R. Murren, Shannon W. Anderson, José Luis Fedele, +8

Journal of Clinical Oncology

Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines.

G Pizzorno, J A Sokoloski, Arlene R. Cashmore, +3

Molecular Pharmacology

Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.

G Pizzorno, Lorrin Yee, Barbara Burtness, +8

PubMed

Molecular PharmacologyMedicinal ChemistryUrologyPharmacological StudiesMedicine +10

Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil

G Pizzorno, Ziran Sun, Robert E. Handschumacher

Biochemical Pharmacology

Oncogenic AgentMedicineColorectal CancerPathologyOncology +4

Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.

G Pizzorno, Rosemary A. Wiegand, S K Lentz, +1

PubMed

Tumor BiologyMedicinal ChemistryOncologyTissue-specific ModulationPyrimidine Metabolism +13