Barbara A. Moroson

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +14

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

G. Peter Beardsley, Barbara A. Moroson, Edward C. Taylor et al. · Journal of Biological Chemistry · 1989 · 230 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.

G Pizzorno, Enrico Mini, Marcella Coronnello et al. · PubMed · 1988 · 110 citations

Medicine, Biochemistry, Pharmacology +15

Amplification of a Polymorphic Dihydrofolate Reductase Gene Expressing an Enzyme with Decreased Binding to Methotrexate in a Human Colon Carcinoma Cell Line, HCT-8R4, Resistant to This Drug

S. Srimatkandada, Barry Schweitzer, Barbara A. Moroson et al. · Journal of Biological Chemistry · 1989 · 101 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +12

Regulation of thymidylate synthetase in mouse leukemia cells (L1210).

Wojciech Rode, Kevin J. Scanlon, Barbara A. Moroson et al. · Journal of Biological Chemistry · 1980 · 94 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13