Lawrence L. Samuels

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

Francis M. Sirotnak, Joseph I. DeGraw, D. M. Moccio et al. · Cancer Chemotherapy and Pharmacology · 1984 · 143 citations

Bioorganic Chemistry, Biochemistry, Natural Sciences +10

Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.

Lawrence L. Samuels, D. M. Moccio, Francis M. Sirotnak · PubMed · 1985 · 72 citations

Chemoprevention Strategy, Cellular Pharmacology, Pharmacotherapy +18

Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse.

Lawrence L. Samuels, L. J. Goutas, David G. Priest et al. · PubMed · 1986 · 53 citations

Normal Tissues, Cellular Enzymology, Biochemistry +13

Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study.

D. M. Moccio, Francis M. Sirotnak, Lawrence L. Samuels et al. · PubMed · 1984 · 28 citations

Folate Compounds, Cellular Physiology, Tumor Biology +19

Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue

Lawrence L. Samuels, Aaron Feinberg, D. M. Moccio et al. · Biochemical Pharmacology · 1984 · 25 citations

Osteosarcoma Patients, Oncology, High-dose Methotrexate/leucovorin Rescue +9