Joseph I. DeGraw

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

Francis M. Sirotnak, Joseph I. DeGraw, D. M. Moccio et al. · Cancer Chemotherapy and Pharmacology · 1984 · 143 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

New folate analogs of the 10-deaza-aminopterin series

Francis M. Sirotnak, Joseph I. DeGraw, Franz A. Schmid et al. · Cancer Chemotherapy and Pharmacology · 1984 · 137 citations

Pharmacy, Biochemistry, Medicinal Chemistry +9

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

Francis M. Sirotnak, Joseph I. DeGraw, William T. Colwell et al. · Cancer Chemotherapy and Pharmacology · 1998 · 92 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin

Joseph I. DeGraw, P. H. Christie, William T. Colwell et al. · Journal of Medicinal Chemistry · 1992 · 77 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

Franz A. Schmid, F. M. Sirotnak, Glenys M. Otter et al. · PubMed · 1985 · 69 citations

Medicine, Medicinal Chemistry, Pharmacology +9