Concepedia

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Huiping Tu, Omar L. Nelson, Arseny Bezprozvanny, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, Ilya Bezprozvanny

Cell · 2006 · 684 citations · 37 references

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37

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

Nelson Arispe, E Rojas, Harvey B. Pollard · Proceedings of the National Academy of Sciences · 1993 · 928 citations

, , +17

Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

Carlos A. Saura, Se‐Young Choi, Vassilios Beglopoulos et al. · Neuron · 2004 · 761 citations · Full text

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Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

Adam Zweifach, Richard S. Lewis · Proceedings of the National Academy of Sciences · 1993 · 755 citations · Full text

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