Lutgarde Serneels

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

Sara Cipolat, Tomasz Rudka, Dieter Hartmann et al. · Cell · 2006 · 727 citations · Full text

Signal Transduction, Mitochondrial Function, Biochemistry +9

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Huiping Tu, Omar L. Nelson, Arseny Bezprozvanny et al. · Cell · 2006 · 681 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +9

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

An Herreman, Dieter Hartmann, Wim Annaert et al. · Proceedings of the National Academy of Sciences · 1999 · 521 citations · Full text

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Lucía Chávez‐Gutiérrez, Leen Bammens, Iryna Benilova et al. · The EMBO Journal · 2012 · 492 citations · Full text

Neurodegenerative Diseases, γ-Secretase Dysfunction, Alzheimer's Disease +6

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

An Herreman, Lutgarde Serneels, Wim Annaert et al. · Nature Cell Biology · 2000 · 481 citations

Embryonic Stem Cell, Developmental Biology, Medicine +10